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Infections within first year of life predicted IBD
The correlation was strongest for onset by age 10 years.
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Induction trough levels predicted ustekinumab response in Crohn’s disease
An ustekinumab trough level of 2.0 mcg/mL or higher distinguished responders from nonresponders with an area under the receiver operating curve of...
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Clock gene disruption might underlie IBD
Multiple clock genes showed reduced mRNA expression in inflamed and uninflamed intestinal mucosa and peripheral white blood cells from patients,...
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AGA Clinical Practice Update: Direct-acting antivirals and hepatocellular carcinoma
For patients listed for liver transplantation, determine timing of DAA therapy on a case-by-case basis, consider regional wait times, availability...
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Ulipristal acetate tops placebo for uterine leiomyomas
Significantly greater improvements in physical and social activities were seen with both ulipristal doses, compared with placebo, from baseline to...
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Study compares tapering strategies in rheumatoid arthritis
Cumulative rates of flare at 1 year were 33% with initial tapering of conventional synthetic DMARDs and 43% with initial TNF-inhibitor tapering (...
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Induction trough levels predicted ustekinumab response in Crohn’s disease
An ustekinumab trough level of 2.0 mcg/mL or higher distinguished responders from nonresponders with an area under the receiver operating curve of...
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Tailoring the Mediterranean diet for NAFLD
Keys to success included providing recipes and meal planners, education on how lifestyle and diet contribute to NAFLD, and offering care in person...
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Positive psoriatic arthritis screens occur often in psoriasis patients
In all, 12.4% of patients had a positive screen for possibly undiagnosed psoriatic arthritis but had never been diagnosed with the disease.
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Gene therapy restored immunity in newly diagnosed SCID-X1
In the phase 1/2 study, seven infants had normal immune cells 3-4 months after treatment, while the eighth infant responded after a gene therapy...
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Look for functional esophageal disorders if GERD patients fail PPIs
Fully 75% of PPI nonresponders had concurrent functional heartburn or reflux hypersensitivity.
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No biopsy for 21% of adults with celiac disease
The iCureCeliac Patient Powered Research Network is supported by the Patient-Centered Outcomes Research Institute. The investigators reported...
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Studies link TMAO to microbiome, reveal new heart disease target
MIAMI – TMAO alters cholesterol and bile acid metabolism, upregulates inflammatory pathways, and promotes foam cell formation, all of which worsen...
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AGA publishes care pathway for IBD in pregnancy
Aminosalicylates, biologics, and immunomodulators can be continued during pregnancy and delivery.
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AGA Clinical Practice Update: Switching between biologics and biosimilars in inflammatory bowel disease
Two large studies have found switching to be safe, but FDA has not designated any biosimilar interchangeable.