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Nuedexta mainly prescribed for dementia, Parkinson’s
Only 15.2% of patients had multiple sclerosis or amyotrophic lateral sclerosis, the diagnoses of patients in the studies leading to the approval...
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Pyrotinib shows promise in HER2-mutant non–small cell lung cancer
In a phase 2 trial of 15 adults with progressive HER2-mutant NSCLC, objective response rate was 53%, median overall survival was 12.9 months, and...
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Childhood inflammatory bowel disease linked to increased mortality
The risk of death was three- to fivefold higher than that in the general population.
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Metachronous advanced neoplasia linked to diminutive polyp number, not histology
Metachronous advanced neoplasia was diagnosed in similar proportions of patients with and without high-risk diminutive polyps.
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Studies support vedolizumab-calcineurin inhibitor combinations but not accelerated infliximab therapy for refractory UC
Rates of colectomy were similar whether patients received induction immunotherapy with infliximab at weeks 0, 2, and 6, or on an accelerated...
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Study supports swallowed topical steroids as maintenance for eosinophilic esophagitis
Rates of clinical remission were 16.1% and 1.3%, respectively (P less than .001).
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Vedolizumab, tofacitinib induced rapid improvements in IBD symptoms
Two recent studies highlight the ability of vedolizumab and tofacitinib to rapidly improve symptoms reported by patients with inflammatory bowel...
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Study eyed endoscopic submucosal dissection for early-stage esophageal cancer
Compared with esophagectomy, ESD was associated with significantly fewer severe adverse perioperative events and a similar rate of all-cause...
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Vedolizumab, tofacitinib induced rapid improvements in IBD symptoms
Both biologics induced clinically meaningful improvements in patient-reported outcomes early in the course of treatment.
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Routine markers predicted histologic response to obeticholic acid in NASH
Significant predictors included baseline nonalcoholic fatty liver disease activity score greater than 5, baseline triglycerides up to 154 mg/dL,...
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Staying up to date on screening may cut risk of death from CRC
Staying up to date on screening was associated with a 62% decrease in the odds of dying from colorectal cancer.
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Budesonide topped placebo for treating lymphocytic colitis
Fully 79% of patients achieved clinical remission with budesonide.
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Maintaining virologic response predicted long-term survival in HBV patients with decompensated cirrhosis
An HBV DNA load less than 20 IU/mL in patients with decompensated cirrhosis significantly improved the chances of long-term survival.
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Norfloxacin might benefit patients with advanced cirrhosis and low ascites fluid protein levels
The mortality benefit appeared to be limited to patients with ascites fluid protein levels under 15 g/L.
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Crohn’s disease tied to anal canal high-risk HPV infection
High-risk HPV DNA was detected in anal tissue specimens from 30% of patients with Crohn’s disease versus 18% of patients without Crohn’s disease...