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H. pylori antibiotic resistance reaches ‘alarming levels’
Resistance to clarithromycin, metronidazole, and levofloxacin reached 15% or more in almost all World Health Organization regions.
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Thiopurines linked to zoster in IBD patients
The adjusted hazard ratio for developing zoster was 1.47 (95% CI, 1.31-1.65; P less than .001) for thiopurine monotherapy, compared with...
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MELD sodium score tied to better transplant outcomes
Factoring hyponatremic status into liver graft allocations led to significant reductions in wait-list mortality.
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Proximal adenoma location does not predict high-grade dysplasia
The odds of high-grade dysplasia were slightly lower for proximal versus distal adenomas.
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ALEX: Alectinib showed superior CNS efficacy in ALK+ NSCLC
Time to CNS progression was significantly longer with alectinib versus crizotinib.
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Guideline: Early screening warranted if family history of nonhereditary colorectal cancer
Initial screening colonoscopy should occur at age 40-50 years, or 10 years before the age of the earliest-diagnosed first-degree relative.
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Admission eosinopenia predicted severe CDI outcomes
Significant predictors of mortality included having more comorbidities and lower systolic blood pressure at admission.
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JACOB: Dual HER2 blockade falls short in metastatic gastric cancer
In contrast to patients with breast cancer, dual HER2 blockade did not significantly improve overall survival in patients with metastatic gastric...
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Proinflammatory diet linked to colorectal cancer testing positive for Fusobacterium nucleatum
Dietary scores in the highest tertile correlated with significantly increased risk (P = .03).
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Commentary: Composite risk, not age, is key for timing first colorectal cancer screening
Age may not be the colorectal cancer screening issue.
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Experts update diagnostic guidelines for eosinophilic esophagitis
The diagnosis no longer needs to include a trial of proton pump inhibitor therapy.
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Cirrhosis study finds no link between screening, liver cancer mortality
Among patients with cirrhosis, screening for hepatocellular carcinoma was not associated with reductions in liver cancer mortality.
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Coagulopathy outbreak underscores danger of synthetic cannabinoids
Four patients died after developing spontaneous intracranial bleeding.
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Atrial fib guidelines may fall short on oral anticoagulation
Oral anticoagulation threshold according to CHA2DS2-VASc score varied widely after accounting for varying stroke rates in published studies.
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AGA Guideline: Treatment of opioid-induced constipation
Laxative therapies, including stimulant laxatives are recommended; for truly laxative-refractory constipation, a trial of peripherally acting mu-...