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HIV and HCV Coninfected Have Higher Hepatic Decompensation Rates
Major finding: About 7.4% of coinfected patients and 4.8% of monoinfected patients had hepatic decompensation at 10 years (hazard ratio, 1.56; 95...
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Patients with both HIV and HCV have higher hepatic decompensation rates, despite antiretrovirals
Major finding: About 7.4% of coinfected patients and 4.8% of monoinfected patients had hepatic decompensation at 10 years (hazard ratio, 1.56; 95...
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Coding practices could bias pneumonia mortality rates, hospital rankings
Major finding: Performance ranking changed for 28% of hospitals when calculations of risk-standardized pneumonia mortality rates included patients...
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Positive surgical margins do not independently predict prostate cancer mortality
Major finding: Positive surgical margins were not significantly associated with prostate cancer–specific mortality within 15 years of radical...
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Patients on palliative chemo more likely to undergo intensive care
Major Finding: Patients receiving palliative chemotherapy were more likely to undergo mechanical ventilation, cardiopulmonary resuscitation, or...
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MS relapse rates higher with 2-month washout before switch to fingolimod
Major Finding: Relapse rates after patients switched to fingolimod were low (quarterly relapse rate range, 0.079-0.13). Predictors of time to...
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Study found low rates, but significant risk factors, for incidental gallbladder cancer in cholecystectomy patients
Major finding: Overall incidence of incidental gallbladder cancer was 0.19%. Risk factors included open vs.
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Adjuvant chemotherapy did not improve survival in rectal cancer
Major finding: Adjuvant fluorouracil-based chemotherapy after preoperative radiotherapy did not affect disease-free survival or overall survival,...
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Genomic analyses led to targeted treatment for metastatic breast cancer, though response rate disappointing
Major finding: Targeted therapy was possible for 13% of patients screened with genomic analyses.
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Vemurafenib improved survival in BRAF mutation–positive metastatic melanoma
Major finding: The median overall survival was 13.6 months for patients receiving vemurafenib compared with 9.7 months for patients receiving...
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Vaginal mesh found superior for vaginal vault prolapse with levator ani avulsion
Major finding: At 1-year follow-up, 3% of the vaginal mesh group met criteria for anatomic failure, compared with 62%-65% of the sacrospinous...
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Maintenance percutaneous tibial nerve stimulation improved bladder symptoms in MS
Major finding: 74 of 83 patients (89%) reported at least 50% improvement after 12 weekly sessions of percutaneous tibial nerve stimulation.
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Early dasatinib response predicted long-term survival in imatinib-resistant chronic phase chronic myeloid leukemia
Major finding: At 6 years of follow-up, patients receiving 100 mg dasatinib daily had an overall survival of 71% and progression-free survival of...
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Hormone therapy predicted improved lung cancer survival in women
Major Finding: Long-term hormone therapy was associated with significantly improved survival in women with non–small-cell lung cancer (HR, 0.54)....