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Novel study explores link between primary immunodeficiencies, rheumatic diseases
Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with...
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IL-23 plays key roles in antimicrobial macrophage activity
Human macrophages showed less antimicrobial activity when transfected with the IL23R-Q381 variant, which is protective against IBD.
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Budesonide orodispersible tablets maintained remissions in EoE
After 48 weeks, 51 patients in the 1-mg group (75%) and 50 patients in the 0.5 mg group (73.5%) remained in remission, compared with only three...
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Diarrhea prevalent among COVID-19 patients with IBD
One in five patients with IBD and COVID-19 had diarrhea, at least twice the prevalence compared with pooled data from prior studies.
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Lusutrombopag found safe, effective for severe thrombocytopenia in patients with hepatocellular carcinoma
Lusutrombopag met the primary efficacy endpoint and did not significantly increase the rate of postprocedural thromboses, compared with placebo....
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AGA Clinical Practice Update: Diagnosis and treatment of small intestinal bacterial overgrowth
For now, a SIBO diagnosis simply means that a patient’s presenting symptoms or laboratory findings are attributed to bacterial changes in the...
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Bariatric surgery achieved long-term resolution of NASH without worsening fibrosis
In all, 84% of patients evaluated at 5 years met this primary endpoint.
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AGA Clinical Practice Update: Young adult–onset colorectal cancer diagnosis and management
In addition to receiving cancer staging or being referred to an oncologist, newly diagnosed patients should be counseled about both germline...
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Scoring system identified patients with suspected small-bowel bleeding
At a cutoff threshold of less than or equal to 0, the negative predictive value of the scoring system was 83.6%, but its positive predictive value...
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Anti-CD8a, anti-IL-17A antibodies improved immune disruption in mice with history of NASH
Treatment with anti-CD8a antibodies decreased cytotoxic T cells in all tissues tested, while antibodies targeting IL-17A reduced hepatic...
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Complete endoscopic healing tied to better Crohn’s disease outcomes
Rates of treatment failure were 25% in patients with complete endoscopic mucosal healing, compared with 48% in patients with partial mucosal...
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Studies eyes risks for poor outcomes in primary sclerosing cholangitis
Significant risk factors included younger age at diagnosis, Afro-Caribbean heritage, and male sex.
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Model identified heavy drinkers at highest risk of ALD progression
Women and men with steatohepatitis had the highest 5-year risk for liver complications.
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Switching to low-inflammatory diet linked to lower risk for Crohn’s disease
In a large observational study, switching from a high-inflammatory diet to a lower-inflammatory diet was associated with a significant decrease in...
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AAP releases new policy statement on barrier protection for teens
The policy statement has been expanded to cover multiple types of sexual activity and methods of barrier protection.