News
Cardiovascular risk assessment required with use of TKIs for CML
Key clinical point: Most patients with chronic myeloid leukemia require long-term tyrosine kinase inhibitor (TKI) therapy, and cardiovascular...
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Tumor-treating fields may improve outcomes in glioblastoma
Key clinical point: Maintenance therapy with tumor-treating fields (TTFields) plus temozolomide resulted in longer survival, compared with...
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Minimal residual disease predicts outcome of allogeneic HCT in acute myeloid leukemia
Patients with acute myeloid leukemia (AML) who are in remission but with minimal residual disease (MRD) have outcomes similar to those of patients...
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SLCO2B1 gene variants may influence ADT outcome
Key clinical point: Single-nucleotide polymorphisms rs12422149 and rs1077858 in the SLCO2B1 gene were associated with time to progression and...
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Treatment delay linked with worse outcome for head and neck cancer
Key clinical point: Patients with time to treatment initiation (TTI) greater than 46-52 days had increased risk of mortality, with greatest risk...
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ADT linked to increased risk of Alzheimer’s disease
Key clinical point: Patients who underwent ADT for prostate cancer had significantly increased risk of future Alzheimer’s disease diagnosis. Major...
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High risk for getting breast cancer linked with low risk of metastasis
Key clinical point: High risk of breast cancer based on specific prediction models was associated with favorable tumor prognosticators and reduced...
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SBRT may be better than RFA for large hepatocellular carcinoma lesions
Key clinical point: Stereotactic body radiotherapy (SBRT) and radiofrequency ablation (RFA) both achieved good local control for small...
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Study finds no benefit from lapatinib for HER2-positive gastric cancer patients
Key clinical point: Addition of lapatinib to capecitabine and oxaliplatin as first-line treatment for HER2-positive advanced gastroesophageal...
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Alectinib shows promise in crizotinib-refractory ALK-rearranged NSCLC
Key clinical point: Alectinib, an oral, small molecule inhibitor of ALK, showed promising clinical activity in crizotinib-refractory patients with...
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No benefit from dual anti-HER2 blockade in early breast cancer
Key clinical point: Adjuvant lapatinib and trastuzumab resulted in similar disease-free survival, compared with trastuzumab alone in early HER2-...
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Childhood, young adult cancer survivors face high risk of long-term morbidity
Key clinical point: Two separate studies demonstrated that survivors of childhood, adolescent, and young adult cancers face high risk of long-term...
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Study: Pediatric cancer patients have high rate of germline mutations in predisposition genes
Key clinical point: Children and adolescents with cancer have a significantly higher rate of germline mutations in cancer predisposition genes...
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Suicide Rate High in Patients With Head and Neck Cancer
Key clinical point: Patients with head and neck cancer have a significantly higher suicide rate than the general population. Major finding: The...