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Targeted therapy, immunotherapy may benefit patients with leptomeningeal metastases from melanoma
Key clinical point: Leptomeningeal metastases from melanoma yield a poor prognosis, but patients may benefit from systemic targeted therapy and...
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Low vitamin D linked with worse outcome in melanoma
Key clinical point: After adjusting for C-reactive protein (CRP), lower vitamin D levels were independently associated with worse outcomes in...
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Farletuzumab may benefit patients with ovarian cancer and low CA-125 level
Key clinical point: Farletuzumab combined with carboplatin and taxane improved progression-free survival (PFS) and overall survival (OS) in...
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Low Vitamin D Linked With Worse Outcome in Melanoma
Key clinical point: After adjusting for C-reactive protein (CRP), lower vitamin D levels were independently associated with worse outcomes in...
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RPS15 mutations prevalent in aggressive chronic lymphocytic leukemia
Key clinical point: Aberrations in the RPS15 gene before therapy may be an indicator of aggressive pathobiology in chronic lymphocytic leukemia....
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Trial supports combined androgen suppression, radiotherapy for prostate cancer
Key clinical point: Adding 6-month androgen suppression (AS) to radiotherapy (RT) at doses of 70 Gy, 74 Gy, or 78 Gy improved biochemical disease-...
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Lenalidomide-dexamethasone yields similar PFS as triplet regimens in elderly multiple myeloma patients
A more intensive induction treatment with the doublet regimen lenalidomide plus low-dose dexamethasone administered for a limited duration (9...
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RECIST underestimates benefit of pembrolizumab in subset of melanoma patients
Key clinical point: Approximately 15% of patients with advanced melanoma treated with pembrolizumab had unique response patterns, and RECIST...
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Mets to liver linked with lowest survival in men with CRPC
Key clinical point: In men with castration-resistant prostate cancer treated with docetaxel, overall survival was worse with liver metastasis than...
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PFS a surrogate for overall survival in soft tissue sarcoma trials
Key clinical point: In randomized trials of advanced soft tissue sarcoma, intermediate endpoints of progression-free survival and response rate...
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HDAC inhibition may reverse anthracycline resistance in patients with sarcoma
Key clinical point: Despite prior exposure to multiple regimens, clinical benefit was observed in several patients with advanced solid tumors,...
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Radiotherapy for prostate cancer linked to higher risk of secondary malignancies
Key clinical point: Radiotherapy for prostate cancer was associated with a higher risk of secondary malignancies of the bladder, colon, and rectum...
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Ki-67 bests cytology, growth pattern as prognostic factor for MCL
Key clinical point: The Ki-67 index was superior to cytology and growth pattern as a prognostic factor in mantle-cell lymphoma (MCL).
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Occult micrometastases in N2 lymph nodes correlated with shorter survival in NSCLC
Key clinical point: Micrometastasis detected by immunohistochemistry (IHC) staining for cytokeratin (AE1/AE3) in the lymph nodes of patients with...
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Prospective study confirms chemo not needed after low Recurrence Score
Key clinical point: Patients with hormone-receptor–positive (HR-positive) breast cancer at high risk for recurrence by traditional parameters, but...