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Acute myeloid leukemia genomic classification and prognosis
Key clinical point: Mutational analysis of 1,540 patients with acute myeloid leukemia (AML) identified 11 distinct classes with prognostic...
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No OS benefit with tasquinimod in mCRPC
Key clinical point: Tasquinimod improved progression-free survival (PFS) but not overall survival (OS) in men with metastatic castration-resistant...
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Baseline PSA at midlife predicts lethal prostate cancer
Key clinical point: Prostate-specific antigen levels at midlife predicted subsequent lethal prostate cancer in men who participated in the...
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In hemophilia A, emicizumab cuts bleeding; plasma-derived factor VIII less likely to trigger antibodies
Key clinical points: Plasma-derived factor VIII carries lower risk of developing neutralizing antibodies than recombinant factor VIII; once-weekly...
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Mutation pattern in non–small-cell lung cancer influenced by increased BMI, smoking
Key clinical point: A prospective epidemiology study found that smoking dose and body-mass index correlated with mutation patterns in non–small-...
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Tamoxifen benefits premenopausal breast cancer patients
Key clinical point: Premenopausal women with ER-positive breast cancer had significantly longer survival with 2 years of adjuvant tamoxifen,...
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Additional D1 biopsy increased diagnostic yield for celiac disease
Key clinical point: When added to a standard D2 biopsy, a single D1 biopsy from any site significantly increased the diagnostic yield for celiac...
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Cirrhosis 30-day readmissions down 40% with quality improvement initiative
Key clinical point: Care protocols implemented by electronic decision support reduced 30-day readmissions of patients with cirrhosis by 40% in an...
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Racial disparities in colon cancer survival mainly driven by tumor stage at presentation
Key clinical point: Tumor stage at diagnosis had a greater effect on survival disparities between black and white patients with colon cancer than...
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Surveillance finds pancreatic ductal carcinoma in situ at resectable stage
Key clinical point: Surveillance of high-risk individuals was relatively successful in detecting pancreatic ductal carcinoma in situ (PDAC) at a...
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Cetuximab monotherapy ineffective in KRAS G13D-mutant mCRC
Key clinical point: In patients with metastatic colorectal cancer and KRAS G13D mutation, cetuximab monotherapy showed no activity, and cetuximab...
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Daratumumab well tolerated, effective in heavily treated multiple myeloma
Key clinical point: Daratumumab was well tolerated and showed encouraging activity in heavily treated patients with multiple myeloma.
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Dose-escalated blinatumomab plus dexamethasone induced responses in relapsed/refractory DLBCL
Key clinical point: Stepwise dose-escalated administration of blinatumomab plus dexamethasone may be effective in patients with relapsed/...
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Older patients with soft tissue sarcoma may receive greater benefit from RT
Key clinical point: For many subtypes of soft tissue sarcoma (STS), overall survival (OS) was significantly greater in older patients who received...
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Factor VIII–mimetic antibody effective in hemophilia A
Key clinical point: The bispecific antibody ACE910 was safe and effective as a long-acting hemostatic drug for hemophilia A in a phase I trial of...