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Model recapitulates cancer susceptibility in DBA
Researchers say they’ve created the first animal model that recapitulates the predisposition to cancer observed in patients with Diamond-Blackfan...
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Study provides clearer picture of JMML
Photo by Petr Kratochvil Whole-exome sequencing has provided new insights that may lead to better treatment of juvenile myelomonocytic leukemia (...
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Drug granted breakthrough designation for ALL
The US Food and Drug Administration (FDA) has granted breakthrough therapy designation for inotuzumab ozogamicin to treat adults with acute...
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Team identifies problems with preclinical research
Poor study design and the tendency to publish positive—but not negative—results threaten the validity of preclinical research, according to an...
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Study reveals potential drivers of CLL
Photo courtesy of Dana- Farber Cancer Institute Researchers say they have identified dozens of genetic abnormalities that may drive chronic...
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NCCN creates tool to aid treatment decisions
patient and her father Photo by Rhoda Baer The National Comprehensive Cancer Network (NCCN) has developed a new tool to accompany its clinical...
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FDA approves reversal agent for dabigatran
treating a patient Photo by Tom Watanabe The US Food and Drug Administration (FDA) has granted accelerated approval for idarucizumab (Praxbind),...
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MMF may increase risk of CNS lymphoma
A new study has linked the immunosuppressive drug mycophenolate mofetil (MMF) to an increased risk of central nervous system (CNS) lymphoma in...
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Watchdog condemns FDA oversight of dabigatran
Photo by ec-jpr The US Food and Drug Administration’s (FDA’s) oversight of the oral anticoagulant dabigatran (Pradaxa) raises questions about the...
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COMP recommends orphan designations for KTE-C19
The European Medicines Agency’s Committee for Orphan Medicinal Products (COMP) has adopted positive opinions recommending orphan designation for...
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Health Canada approves drug for acquired hemophilia A
Photo courtesy of Baxter International Inc. Health Canada has approved a recombinant porcine factor VIII (FVIII) product (Obizur) to treat...
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Donor’s lack of sleep may impact HSCT
Sleep-deprived mice make poor donors for hematopoietic stem cell transplants (HSCTs), according to a study published in Nature Communications....
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Targeting a protein to improve AML treatment
Photo courtesy of VCU Massey Cancer Center Preclinical experiments have shown that blocking production of the protein CHD4 may help increase the...
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Computerized cognitive training benefits childhood cancer survivors
Conklin and Jason Ashford Photo courtesy of St.
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Malarial protein is basis for potential cancer therapy
Photo by Vivian Sum A protein expressed by the malaria parasite Plasmodium falciparum may prove useful for treating a range of cancers, according...