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Study challenges ‘textbook’ view of hematopoiesis
University Health Network Results of a study published in Science challenge traditional ideas about how blood is made. The findings suggest...
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Donor CAR T cells treat aggressive ALL in infant
person treated with UCART19 Photo courtesy of GOSH A hospital in the UK has reported success with the first-in-human use of an allogeneic...
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FDA: Long-term clopidogrel doesn’t affect risk of death
A review conducted by the US Food and Drug Administration (FDA) indicates that long-term use of the antiplatelet drug clopidogrel (Plavix) does...
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RIC can improve HSCT outcomes in older AML patients
Photo by Chad McNeeley Results of a phase 2 study suggest that reduced-intensity conditioning (RIC) may allow older patients with acute myeloid...
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FDA grants drug priority review as FL therapy
The US Food and Drug Administration (FDA) has accepted for priority review a supplemental biologics license application for obinutuzumab (Gazyva)...
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France to lift lifetime ban on MSM blood donors
Photo by Михаило Јовановић France is planning to lift its lifetime ban on blood donations from men who have sex with men (MSM), and the change is...
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EC expands indication for azacitidine in AML
The European Commission (EC) has expanded the approved indication for azacitidine for injection (Vidaza) in acute myeloid leukemia (AML). Now,...
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Experiment reveals new method of RBC production
Photo courtesy of Josh Barney/University of Virginia Health System An unexpected result of a lab experiment has led researchers to a new way to...
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HSC self-renewal depends on surroundings
in the bone marrow Scientists say that, using a model of the hematopoietic system, they have determined which signaling pathways play an...
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Autophagy works in nucleus to ward off cancer
Image by Sarah Pfau Autophagy works in the cell nucleus to guard against the start of cancer, according to research published in Nature. The...
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A new category of cytopenias
New research suggests that clonality may underlie the cytopenias observed in patients with idiopathic cytopenias of undetermined significance (...
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Duo solves mystery regarding FVIII
Turner and Joel Moake Photo from Rice University A pair of researchers solved a long-standing mystery about where factor VIII (FVIII) is made,...
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Drug gets orphan designation for BPDCN
The European Medicines Agency (EMA) has granted orphan drug designation to SL-401 for the treatment of blastic plasmacytoid dendritic cell...
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Protocol could improve massive blood transfusion
An “early and aggressive” approach to massive blood transfusion can save lives in military combat zones and may provide the same benefit in...
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MM-related ESRD on the decline
Photo by Anna Frodesiak New research suggests the risk of end-stage renal disease (ESRD) caused by multiple myeloma (MM) is declining, and...