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Axonal Loss in Optic Neuritis

Studying damage to the RNFL and GCC

Publish date:: December 18, 2015

All subtypes of optic neuritis (ON) have a significant effect on both the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC), according to a study of 118 Chinese patients with ON, including 62 with multiple sclerosis and ON (MS-ON), 19 with recurrent ON (R-ON), 37 with neuromyletis optica and ON (NMO-ON), as well as 68 healthy controls. Researchers found:

• Both the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were significantly thinner in all ON subtypes vs controls.

• R-ON and NMO-ON groups showed more severe damage on the RNFL and GCC pattern.

Citation: Tian G, Li Z, Zhao G, et al. Evaluation of retinal nerve fiber layer and ganglion cell complex in patients with optic neuritis or neuromyelitis optica spectrum disorders using optical coherence tomography in a Chinese cohort. [Published online ahead of print November 15, 2015]. J Ophthalmol. doi: 10.1155/2015/832784.

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