The FDA has approved Clenpiq, which is composed of sodium picosulfate, magnesium oxide, and anhydrous citric acid, as an oral solution to clean out the colon in adults preparing to undergo colonoscopy.

Indications: The oral solution is indicated in patients preparing for a colonoscopy to detect colon cancer and provides a ready to drink, low volume formulation that is premixed. The cranberry-flavored drink has a 2-fold mechanism of action. Sodium picosulfate works as a stimulant laxative while magnesium oxide and anhydrous citric acid act as an osmotic laxative.

Dosage and administration: 1 bottle of premixed solution is considered 1 dose and 2 doses of the product are needed for complete preparation for colonoscopy. The recommended method of administration is as a split dose.

Adverse reactions: Most common adverse reactions, which occur in >1% of patients, are nausea, headache, and vomiting.