Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Increased Risk of Acute MI and HF with IBD

Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al

Patients with inflammatory bowel diseases (IBD), including Crohn’s disease (CD), are at increased risk for acute myocardial infarction (AMI) and heart failure (HF), a recent study found. Researchers identified 736 patients diagnosed with IBD in Olmsted County, MN, from 1980 through 2010. They were matched 1:2 to randomly selected individuals without IBD (controls, n=1,472). Primary outcomes were AMI and HF. Among the findings:

  • After adjustment for traditional cardiovascular disease (CVD) risk factors, IBD associated independently with increased risk of AMI (adjusted hazard ratio [aHR], 2.82) and HF (aHR, 2.03).
  • The relative risk of AMI was significantly increased in patients with CD (aHR vs controls, 2.89) or ulcerative colitis (UC) (aHR vs controls, 2.70).
  • The relative risk of HF was significantly increased among patients with UC (aHR, 2.06), but not CD.
  • The relative risk of both AMI and HF was increased among users of systemic corticosteroids.

Citation:

Aniwan S, Pardi DS, Tremaine WJ, Loftus Jr EV. Increased risk of acute myocardial infarction and heart failure in patients with inflammatory bowel diseases. [Published online ahead of print April 24, 2018]. Clin Gastroenterol Hepatol.