Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Increased Risk of Acute MI and HF with IBD
Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al
Patients with inflammatory bowel diseases (IBD), including Crohn’s disease (CD), are at increased risk for acute myocardial infarction (AMI) and heart failure (HF), a recent study found. Researchers identified 736 patients diagnosed with IBD in Olmsted County, MN, from 1980 through 2010. They were matched 1:2 to randomly selected individuals without IBD (controls, n=1,472). Primary outcomes were AMI and HF. Among the findings:
- After adjustment for traditional cardiovascular disease (CVD) risk factors, IBD associated independently with increased risk of AMI (adjusted hazard ratio [aHR], 2.82) and HF (aHR, 2.03).
- The relative risk of AMI was significantly increased in patients with CD (aHR vs controls, 2.89) or ulcerative colitis (UC) (aHR vs controls, 2.70).
- The relative risk of HF was significantly increased among patients with UC (aHR, 2.06), but not CD.
- The relative risk of both AMI and HF was increased among users of systemic corticosteroids.
Aniwan S, Pardi DS, Tremaine WJ, Loftus Jr EV. Increased risk of acute myocardial infarction and heart failure in patients with inflammatory bowel diseases. [Published online ahead of print April 24, 2018]. Clin Gastroenterol Hepatol.
This Week's Must Reads
Must Reads in Crohn’s Disease
Ustekinumab & Health-Related Quality of Life in CD, J Crohns Colitis; ePub 2018 May 3; Sands, et al
Increased Risk of Acute MI and HF with IBD, Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al
Opioid Use Disorder & IBD Hospitalizations, J Crohns Colitis; ePub 2018 May 7; Cohen-Mekelburg, et al
Clinical Course of IBD with Celiac Disease, J Crohns Colitis; ePub 2018 May 7; Tse, et al
Incidence of Intestinal Infections in IBD, Inflamm Bowel Dis; ePub 2018 May 2; Barber, et al