Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Incidence of Intestinal Infections in IBD
Inflamm Bowel Dis; ePub 2018 May 2; Barber, et al
The incidence of intestinal infections has increase over the past 15 years among hospitalized patients with inflammatory bowel disease (IBD), primarily driven by Clostridium difficile infections. Researchers analyzed the National Inpatient Sample (NIS) for hospitalizations from IBD between 1998 and 2014. Incidence for each infection was calculated for Crohn’s disease (CD) and ulcerative colitis (UC). They found:
- There were 4,030,620 hospitalizations for IBD during the study period.
- The annual incidence of intestinal infections rose from 26.2 to 70.6 infections per 1,000 IBD hospitalizations.
- A main driver of the rising incidence was C.diff infections, which increased from 7.8 to 32.1 per 1,000 CD hospitalizations and from 23.0 to 84.7 per 1,000 UC hospitalizations.
- Intestinal infections were associated with longer length of stay and greater all-cause mortality.
Barber GE, Hendler S, Okafor P, Limsui D, Limketkai BN. Rising incidence of intestinal infections in inflammatory bowel disease: A nationwide analysis. [Published online ahead of print May 2, 2018]. Inflamm Bowel Dis. doi:10.1093/ibd/izy086.
This Week's Must Reads
Must Reads in Crohn’s Disease
Ustekinumab & Health-Related Quality of Life in CD, J Crohns Colitis; ePub 2018 May 3; Sands, et al
Increased Risk of Acute MI and HF with IBD, Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al
Opioid Use Disorder & IBD Hospitalizations, J Crohns Colitis; ePub 2018 May 7; Cohen-Mekelburg, et al
Clinical Course of IBD with Celiac Disease, J Crohns Colitis; ePub 2018 May 7; Tse, et al
Incidence of Intestinal Infections in IBD, Inflamm Bowel Dis; ePub 2018 May 2; Barber, et al