Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Acetaminophen & NSAIDs and Risk of Crohn’s Disease
Ailment Pharmacol Ther; ePub 2018 Apr 5; Moninuola, et al
There is no consistent association between nonsteroidal anti-inflammatory drugs (NSAIDs) use or acetaminophen use and risk of Chron’s disease (CD) and ulcerative colitis (UC) exacerbation, a recent study found. The systematic review and meta-analysis identified 18 publications and abstracts between 1983 and 2016. Researchers found:
- For the meta-analysis, pooled relative risks (RR) of disease exacerbation with NSAIDs use were (1.42), I2 = 60.3% for CD, and (1.52), I2 = 56.1% for UC.
- The corresponding values for acetaminophen use were (1.4), I2 = 45.6% for UC, and (1.56), I2 = 0.0% for IBD.
- Sensitivity analyses limited to studies with low risk of bias showed a significantly increased risk of CD exacerbation, but not UC, with NSAIDs use.
Moninuola OO, Milligan W, Lockhead P, Khalili H. Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn’s disease and ulcerative colitis exacerbation. [Published online ahead of print April 5, 2018]. Ailment Pharmacol Ther. doi:10.1111/apt.14606.
This Week's Must Reads
Must Reads in Crohn’s Disease
Ustekinumab & Health-Related Quality of Life in CD, J Crohns Colitis; ePub 2018 May 3; Sands, et al
Increased Risk of Acute MI and HF with IBD, Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al
Opioid Use Disorder & IBD Hospitalizations, J Crohns Colitis; ePub 2018 May 7; Cohen-Mekelburg, et al
Clinical Course of IBD with Celiac Disease, J Crohns Colitis; ePub 2018 May 7; Tse, et al
Incidence of Intestinal Infections in IBD, Inflamm Bowel Dis; ePub 2018 May 2; Barber, et al