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Jury still out on mortality benefits of knee replacement in OA
People with osteoarthritis who go on to have a knee replacement do not appear to have an increased risk of all-cause mortality, but the jury is...
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Early RA remission more unstable in the presence of foot synovitis
Clinicians should consider escalating therapy in patients with early RA who have persistent foot synovitis regardless of disease activity status,...
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New gout drug under investigation has dual benefit
Key clinical point: The investigational uricosuric drug arhalofenate significantly reduced the incidence of flares in gout patients and also...
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Genetics, smoking, and inflammation on MRI predict progression in axial SpA
In patients with early axial spondyloarthritis, progression to structural damage is slow, but those who do progress are more likely to be a...
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Gut microbiota plays undefined role in liver disease
The development and progression of fatty liver, alcoholic and nonalcoholic diseases appear to be influenced by gut microbiota but it is too early...
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Terlipressin does not reverse hepatorenal syndrome but improves survival
Treating patients with hepatorenal syndrome type 1 with the synthetic vasopressin analogue terlipressin (Lucassin) and albumin does not improve...
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Anti-Remicade antibodies also cross-react with infliximab biosimilar
Key clinical point: Rheumatology patients with positive antibodies to Remicade should not be switched to infliximab biosimilar (Remsima, Inflectra...
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Severe dengue fever outcomes predicted via metabolomics
The progression of dengue fever into life-threatening dengue hemorrhagic fever or dengue shock syndrome can be predicted by analyzing patient...
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Minimal disease activity criteria in PsA fall short
The minimal disease activity criteria used to identify low disease activity in psoriatic arthritis (PsA) may not be useful as a treatment target...
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Subtle radiographic progression in axial SpA cannot be reliably distinguished from error
Key clinical point: Subtle radiographic progression in axSpA cannot be reliably distinguished from measurement error. Major finding: Using plain...
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Subclinical inflammation predicts progression from psoriasis to PsA
People with cutaneous psoriasis who have arthralgia and signs of subclinical inflammation on MRI are at an increased risk of progressing to...
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Ultrasound could help identify patients suitable for biologic tapering
Ultrasound evaluation at the time of clinical remission could be a useful tool to select the most appropriate RA patients to undergo biologic...
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NSAIDs effective and safe for axSpA in the short term
The findings of a recent Cochrane review back up guidelines that recommend NSAIDs as an appropriate first-line treatment for people with axial...
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Alcohol withdrawal patients on sedative infusions may not need pre-emptive intubation
Key clinical point: Pre-emptive intubation may not be necessary in patients with alcohol withdrawal syndrome who are treated in hospital with...
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COPD Exacerbation Amps Up Stroke Risk
Key clinical point: Risk for stroke is 6.7-fold higher in the 7 weeks after an acute exacerbation of COPD. Major finding: People with COPD had a 6...