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Brain connectivity in depression tied to poor sleep quality
An increase in functional connectivity in certain brain regions of people with depression could explain the link between the disease and poor...
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Liver enzyme a marker of disease progression in primary biliary cholangitis
The liver enzyme autotaxin may be a useful noninvasive marker of disease progression in people with primary biliary cholangitis, new research has...
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Anticholinergics’ link to dementia calls for vigilance in elderly
The associations seen were “moderate” but reflect an “appreciable risk” for patients.
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MRI finds PML in some natalizumab-treated patients despite negative CSF, no symptoms
Correlation also observed between viral load and lesion volume.
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Low vitamin B12 tied to worsening mobility, cognition in early Parkinson’s
Increased level over time didn’t necessarily lead to better outcomes.
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Intramuscular steroid injection reduced hip OA pain up to 12 weeks
Results at 12 weeks called surprising.
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Gut bacteria could drive autoimmune response in genetically predisposed
Studies of a mouse model and humans reveal potential pathologic links of gut bacteria to lupus and autoimmune hepatitis.
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Phosphodiesterase-5 inhibitors often prescribed inappropriately
Clinical guidelines and advice from the Choosing Wisely campaign recommend against the routine use of pulmonary vasodilators for patients with...
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Immunotherapy regimen influences inflammatory arthritis presentation
Variations in the clinical presentation of immunotherapy-induced inflammatory arthritis is partly explained by which treatment regimen is used to...
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Trial shows ‘signals’ in favor of general anesthesia during EVT for stroke
The results from the randomized trial run “contrary to numerous nonrandomized studies.”
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Researchers identify three distinct clinical-histologic-genetic subtypes in RA
The findings could be clinically meaningful and may help guide optimal treatment strategies for patients.
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ANA assay results differ widely in established lupus patients
Study results call into question the use of assays to determine trial eligibility and their role in clinical practice.
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ACR sounds more welcoming tone in new biosimilars position paper
But in a related editorial Dr. Roy Fleischmann notes that there are still many concerns regarding biosimilars.
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Checkpoint inhibitors look safe in rheumatology patients
The Mayo Clinic analysis examines 16 patients with rheumatologic diseases and cancer who received checkpoint inhibitor therapy.
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Ultrasound could have utility in predicting which RA patients stay in remission
The short-term predictive power of ultrasound-detected residual synovitis may be more significant than its long-term predictive power.