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Atezolizumab doubles survival of NSCLC patients with poor performance status
Patients typically excluded from clinical trials because of age or comorbidities had better survival with atezolizumab than single-agent...
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A farewell to arms? Drug approvals based on single-arm trials can be flawed
Objective responses, not time-dependent survival outcomes, should be endpoints for single-arm trials, with results only used for conditional...
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Lung volume reduction methods show similar results for emphysema
“Until now there had been no direct comparison of the two to inform decision-making.”
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Pembro/chemo combo fails to improve event-free survival in head and neck cancer
Some trends favored chemoradiation plus pembrolizumab over chemoradiation alone, but KEYNOTE-412 failed to meet primary endpoint.
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‘Smoking gun–level’ evidence found linking air pollution with lung cancer
The finding could lead to strategies for preventing lung cancer in nonsmokers exposed to high levels of foul air.
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Biomarker-guided steroid therapy shown safe for COPD
“A personalized endotype-based treatment with oral prednisolone is possible in patients with COPD.”
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RETHINC takes air out of COPD-like therapy for smokers
Bronchodilator therapy was no better than placebo at reducing respiratory symptoms in smokers without airway obstruction.
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Tumor-bed radiotherapy boost reduces DCIS recurrence risk
Regardless of the whole breast irradiation fractionation schedule, a 16 Gy tumor-bed boost halved the risk of DCIS recurrence at 5 years.
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Skip chemoRT in low-risk nasopharyngeal cancer?
There were no differences in efficacy for patients treated with radiation plus concurrent chemoradiation vs. radiation alone in a randomized trial...
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Air pollution contribution to lung cancer may be underestimated
A study of women with lung cancer who never smoked suggests that air pollution may be a larger risk factor for lung cancer than currently...
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Smoking cessation with lung screening ups quit rates
Offering smoking cessation support at the time and place of lung cancer screening resulted in high smoking abstinence rates at 1 year.
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ORATOR2 mute on best de-escalation therapy for low-risk HPV+ oropharynx cancers
The trial was halted early due to excess deaths in the surgery arm before type of optimal deescalation therapy could be answered.
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Node-negative triple-negative breast cancer prognosis lies within stromal lymphocytes
Every 10% increase in stromal tumor-infiltrating lymphocytes was associated with a 19% reduction in the risk of death.
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High deductible insurance linked to delayed advanced cancer diagnosis
Time to diagnosis of metastatic cancer increased by nearly 5 months for patients whose employers switched them to high-deductible health insurance...
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Transplanted pig hearts functioned normally in deceased persons on ventilator support
The experimental procedure could enable future widespread use of xenotransplantation to treat end-stage heart failure.