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Opioids increase risk for all-cause deaths in RA vs. NSAIDs
The incidence of all-cause mortality was higher for patients with rheumatoid arthritis who started on opioids rather than NSAIDs for pain control...
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Prednisone, colchicine equivalent in efficacy for CPP crystal arthritis
In an open-label, randomized trial, one in five patients on colchicine had diarrhea, tipping the safety scales in favor of prednisone.
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Steroids and G-CSF improve 90-day survival in severe alcoholic hepatitis
In addition to its superior results on the primary endpoint of 90-day survival, combination therapy was associated with significantly better...
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Retention rates high after biosimilar-to-biosimilar switch for inflammatory arthritis
Danish investigators studied how a government-mandated switch from one infliximab biosimilar to another affected patients with inflammatory...
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First recommendations for cancer screening in myositis issued
The guideline, based on data from a systematic review and meta-analysis and on consensus from an international team of experts and patients,...
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World falls short on HBV, HCV elimination targets
“As countries progress toward eliminating hepatitis B and C, we really need to do more to expand political will and financing of national...
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Resmetirom reduces liver, CV risk factors in NASH with cirrhosis
“I do think it could be one of the drugs that really improves outcomes for patients with NASH.”
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NAFLD progresses to cirrhosis in young and old at similar rate
Risk factors for NAFLD vary with age, but all patients experience similar progression of advanced disease once it develops.
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High-quality index colonoscopies pay off down the road for low-risk patients
Later risk for advanced adenomas, serrated polyps, or colorectal cancer was lower for patients with an initial high-quality colonoscopy.
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Easier bowel prep recipe yields real-world results
A reduced-volume bowel prep formulation was safe and was associated with high rates of adequate or better cleansing in a large practice-based...
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Some young CRC patients are missing out on genetic counseling, testing
Genetic counseling and testing of patients under 50 with CRC have improved over the last decade, but about 20% of patients still don’t get...
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EUS-guided RF ablation doubles survival for unresectable pancreatic cancer
Endoscopic ultrasound–guided radiofrequency ablation of tumors improved overall survival compared with standard of care.
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Mucus unplugged
Investigators seek balance between preserving mucus’s protective function and reducing oversecretion in inflammatory lung diseases.
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Sotorasib superior to docetaxel in KRAS G12C–mutated NSCLC
In its first randomized, phase 3 comparison trial, the first-in-class agent sotorasib held its own against the standard of care docetaxel.
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Obstructive sleep apnea linked to unprovoked VTE
People should be made aware of these links and try to make lifestyle changes to reduce their risk of OSA.