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DKMS: Small nonprofit to world’s largest stem cell donor registry
A German family’s tragedy launched DKMS, a multinational organization whose goal is to “delete blood cancer.”
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TKI/BiTE combo extends survival of older patients with Ph+ALL
In these elderly patients who are not candidates for chemo, the issue is whether we can prolong remission by the addition of other treatments,...
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Adaptive therapy borrows from nature to keep rhabdomyosarcoma in check
Researchers are applying evolutionary principles to the treatment of childhood, fusion-positive rhabdomyosarcoma.
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AGILE: ‘Exciting’ survival results for IDH1-mutated AML
Results show survival that is three times longer for a combination of ivosidenib plus azacitidine versus azacitidine alone in a distinct...
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Isatuximab added to RVd boosts response in new myeloma
A drug approved in 2020 for treatment of advanced multiple myeloma has been shown to benefit patients newly diagnosed with the disease.
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‘Outstanding data’: Mosunetuzumab in r/r follicular lymphoma
If approved by the FDA, mosunetuzumab has the potential to be a first-in-class CD20xCD3 T-cell engaging bispecific antibody in non-Hodgkin...
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‘Remarkable’ results with CAR T cells could make chemo obsolete
“It’s really remarkable that the results are so far in favor of the CAR T-cell therapy that I think it’s inevitable that this will become the...
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Liver cancer risk lingers even after HCV eradication
Not having a sustained viral response was associated with a more than sevenfold higher risk for liver cancer in a multicenter study.
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ASH meeting: Diversity, inclusion, immunotherapy, and COVID-19
“While there have been many advances in the treatment of acute myeloid leukemia ... addressing end-of-life issues is an often neglected area.”
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NAFLD, ALD prevalent among teens, young adults
It’s important to “mitigate modifiable risk factors to prevent disease development and disease progression to potentially advanced fibrosis and...
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In pill or food form, healthy fatty acids reduce liver fat
For patients with NAFLD who supplement their diets with polyunsaturated fatty acids, liver and metabolic parameters improve, results of a...
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Immunotherapies for children with r/r ALL face off
Outcomes were better with tisagenlecleucel vs. blinatumomab in an indirect comparison, but clinical indications should determine which agent to...
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Adding rituximab to belimumab offers no help for lupus
The combination of rituximab and belimumab was associated with a longer duration of response, but there was no benefit of belimumab alone for...
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Allopurinol proves noninferior to febuxostat for gout relief
A randomized, treat-to-target trial showed that the two urate-lowering therapies were comparably effective and safe at doses titrated to target,...
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When a JAK inhibitor fails for a patient with RA, what’s next?
Cycling to a second JAK inhibitor and switching to a biologic disease-modifying antirheumatic drug were equally effective at ameliorating...