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Gene signature may spare some breast cancer patients from radiation
The POLAR 16-gene mRNA signature accurately identified patients who were unlikely to benefit from radiotherapy after breast-conserving surgery.
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‘Exciting’ responsiveness to talquetamab for r/r MM
The novel antibody talquetamab may buy time for patients with multiple myeloma (MM) for whom few other options remain.
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Pricey gene therapy looks cost-effective for SCD
Researchers calculated that a costly new treatment being developed for sickle cell disease (SCD) promises to be worth the price.
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A bold national plan to eliminate HCV by 2050
“We don’t get to use the ‘eliminate’ word all that often with a disease that’s taking thousands or tens of thousands – or worldwide, hundreds of...
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High response rates with T-DXd in early HER2-low breast cancer
Nearly 70% of patients with hormone receptor-positive breast cancers with low levels of HER2 had pathological response to the antibody-drug...
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‘Clear answer’: ALL study defies conventional wisdom
Research on pediatric blood cancers found that high-dose methotrexate does not help cut the risk for central nervous system relapse.
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‘Astonishing’ results: Skip salvage chemo, proceed to HSCT
New research on treating acute myeloid leukemia suggested that some patients may safely go straight to stem cell transplantation.
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Oral SERD camizestrant prolongs PFS vs. fulvestrant in breast cancer
The investigational selective estrogen receptor degrader showed efficacy in advanced ER+/HER2– breast cancers, including patients with ESR1...
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Chemotherapy meets its match against aggressive ER+/HER2– breast cancers
Ribociclib plus endocrine therapy resulted in high response rates and double progression-free survival over combo chemotherapy.
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Potential cause of worse outcomes among Black breast cancer patients found
Tumor microenvironment of metastasis doorways predicted worse outcomes in Black women with residual ER+/HER2– cancer after neoadjuvant...
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ASH 2022: New clinical data challenge long-held assumptions
Fresh research to be unveiled at the 2022 American Society of Hematology conference seems to overturn conventional wisdom across a range of issues...
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Poor NAFLD outcomes with increased VCTE-measured liver stiffness
The findings show that “progression to LSM-defined cirrhosis by VCTE is strongly associated with poor clinical outcomes.”
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New ACR vaccination guideline: Take your best shot
Vaccinate patients with rheumatic and musculoskeletal disease against flu and other vaccine-preventable disease whenever possible, experts say.
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Midodrine may be comparable to albumin for PICD prevention in ACLF
Given the small size of the open-label study, with only 25 patients in each arm, the results should be considered as proof of concept and need to...
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Randomized trial finds community-based weight-loss programs ease knee OA pain
Participants who dieted and exercised in a community-based randomized trial had reductions in knee pain at 18 months; controls also improved...