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MASLD, MASH projected to grow by 23% in the U.S. through 2050
“In the absence of effective treatments, health systems should plan for large increases in the number of liver cancer cases and the need for liver...
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ACORN: No excess AKI with pip-tazo vs. cefepime
Results of the randomized trial suggest that clinicians can safely prescribe empiric piperacillin-tazobactam for serious acute infections.
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Race-specific lung-function values may skew IPF testing
Race-specific equations may falsely inflate percent-predicted pulmonary function values in non-White patients, investigators caution.
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Dato-DXd trumps chemo in advanced HR+/HER2– breast cancer
The antibody-drug conjugate datopotamab deruxtecan had better efficacy and safety than chemotherapy for patients with endocrine-resistant...
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Sputum microbiome may augur treatment success in NTM-PD
Patients cured of nontuberculosis mycobacterial infections with antibiotics had greater species diversity in sputum than those with refractory...
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ICIs improve pCR rates in early ER+/HER2– breast cancer
Nivolumab and pembrolizumab boosted pathologic complete response rates when added to neoadjuvant and adjuvant therapy in patients with high-risk...
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No benefit to adding ICI to chemo in triple-negative breast cancer: study
There were no differences in 5-year event-free survival among patients with TNBC who received neoadjuvant chemotherapy with or without...
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Adjuvant abemaciclib-ET combo shows long-term benefit in high-risk early breast cancer
Invasive disease–free and distant recurrence–free survival were better with the CDK4/6 inhibitor plus endocrine therapy than endocrine therapy...
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Asthma severity higher among LGBTQ+ population
SGM respondents were significantly more likely to have had asthma attacks requiring steroid use in the past years.
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Pulmonary hypertension increases ARDS mortality risk
The presence of PH was associated with about a 50% higher risk for in-hospital mortality.
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The dawning age of therapy for Friedreich ataxia
The first therapy to target the underlying pathology of Friedreich ataxia was approved in 2023. Other drug and genetic therapies are in the...
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Nintedanib dose reductions in IPF may do no harm
Patients with idiopathic pulmonary fibrosis who required dose reductions had similar all-cause mortality and death rates vs. patients on the full...
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Dietary changes to microbiome may improve lung function
What we eat and what’s in the gut may influence lung health for better or worse.
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Head, neck cancer radiotherapy regimen saves time when resources limited
A randomized controlled trial conducted in low- to middle-income countries showed that 11.5 days could be safely shaved off a conventional...
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Reducing cognitive impairment from SCLC brain metastases
Stereotactic radiosurgery was better at preventing loss of verbal recall function at 3 months than whole-brain radiation therapy, the current...