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HDAC/HMA combo shows ‘remarkable’ activity in PTCL
LUGANO, SWITZERLAND – Patients with AITL and PTCL-TFH subtypes had high overall response rates to romidepsin and AZA.
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Bevacizumab or pemetrexed, but not both, efficacious for NSCLC maintenance
The combination of bevacizumab and pemetrexed did not improve survival and had significantly worse toxicity than bevacizumab alone.
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High EPclin score equals chemo benefit in ER+/HER2– breast cancer
Women with high EPclin scores would be likely to have an absolute benefit from chemotherapy added to endocrine therapy, a mathematical model...
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ctDNA may predict relapse risk in early breast cancer
Circulating tumor DNA was associated with a significant risk for relapse in women treated for early primary breast cancers.
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Mixed results with TMB as NSCLC marker
Tumor mutational burden in non–small cell lung cancer varies according to histology and tumor sample location.
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BRCA2 mutations linked to childhood NHL
Survivors of childhood non-Hodgkin may be at significantly increased risk for breast, ovarian, prostate, and other BRCA2-associated cancers.
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Study outlines survival factors with nivolumab
Absence of bone or liver metastases and excellent baseline performance status are linked to 5-year OS in melanoma, RCC, and NSCLC treated with...
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Chemo-free combo gets high response rate in relapsed or refractory DLBCL
LUGANO, SWITZERLAND – Lenalidomide plus the anti-CD19 antibody tafasitamab was associated with a 60% overall response rate.
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On second thought, lenalidomide does improve DLBCL outcomes
LUGANO, SWITZERLAND – Adding lenalidomide to R-CHOP reduced the risk of diffuse large B-cell lymphoma progression or death by 34% in the ECOG-...
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Acalabrutinib extends PFS in advanced CLL
AMSTERDAM – Monotherapy with the Bruton tyrosine kinase inhibitor acalabrutinib offered better progression-free survival, compared with rituximab-...
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Ibrutinib tops chlorambucil against CLL
AMSTERDAM – The Bruton’s tyrosine kinase inhibitor was associated with a halving of risk for death, compared with chlorambucil.
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R2-CHOP doesn’t improve survival in DLBCL
LUGANO, SWITZERLAND – The ROBUST trial is the latest in a long line of studies that failed to show improvement in outcomes with the addition of a...
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No benefit with rituximab after first CR in DLBCL
AMSTERDAM – Rituximab maintenance was no better than observation for patients in first complete remission after induction chemotherapy with R-CHOP...
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AML variants before transplant signal need for aggressive therapy
AMSTERDAM – Patients who had genomic evidence of a lingering AML variant had worse posttransplant outcomes when they underwent reduced-intensity...
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5F9 plus rituximab take a bite out of drug-resistant NHL
AMSTERDAM – The combination thwarts a mechanism that non-Hodgkin lymphomas use to evade immune surveillance.