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Survival gains in HR+/HER2– MBC trials yet to be seen in real world
The introduction of nine new systemic adjuvant therapies did not change survival outcomes for patients with HR+/HER2- metastatic breast cancer.
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Single-fraction radiation just misses mark for spinal compression relief
The primary noninferiority endpoint was not met, but a small difference between single- and multi-fraction radiation may not be clinically...
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Transfusion-related lung injury is on the rise in elderly patients
SAN ANTONIO – Researchers at the Food and Drug Administration examined trends in potentially life-threatening or fatal transfusion-related adverse...
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Cancer pain management inadequate in opioid-saturated areas
Less than one-fourth of cancer patients in rural southwest Virginia received prescription opioids, suggesting suboptimal pain management.
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Getting high heightens stroke, arrhythmia risks
Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies.
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Best practice alerts really can work
SAN ANTONIO – A majority of alerts triggered by red blood cell orders were overridden, but for sound clinical reasons, investigators found.
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First NCCN guideline on hematopoietic cell transplantation focuses on GVHD
Diagnosis and management of both acute and chronic graft-versus-host disease is at the core of the recommendations.
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Trifluridine/tipiracil effective in metastatic gastric cancer after gastrectomy
FTD/TPI was associated with significantly better overall survival and progression-free survival than placebo in patients who had undergone...
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Fresh RBCs offer no benefit over older cells in pediatric ICU
SAN ANTONIO – Exposure to fresh red cells may be associated with immune suppression because viable white cells may also be present in the product...
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ART traces in donor samples show risk to blood supply
Metabolites of drugs used in HIV infection prophylaxis were found in a small proportion of blood samples from HIV-negative donors.
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Fibrinogen concentrate effective, safe for postop bleeding
SAN ANTONIO – Favored more in Europe than North America, fibrinogen concentrate was noninferior to cryoprecipitate for control of bleeding after...
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SPARTAN: Apalutamide delays second progression in nonmetastatic CRPC
BARCELONA – The androgen receptor inhibitor also appeared to show an overall survival benefit, but it did not reach significance in an interim...
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Atezolizumab plus chemo gives slight PFS edge in mUC
BARCELONA – Adding the immune checkpoint inhibitor atezolizumab to platinum-based chemotherapy offered a modest PFS benefit over chemotherapy...
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Ribociclib/fulvestrant boosts survival in advanced breast cancer
BARCELONA – The median overall survival for patients who received the CDK4/6 inhibitor plus fulvestrant has not been reached in the MONALEESA-3...
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PARP inhibitor prolongs PFS in mCRPC
BARCELONA – The PROfound trial shows that targeted therapy can be effective against metastatic castration-resistant prostate cancer bearing DNA...