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Durable transfusion independence in MDS with imetelstat
AMSTERDAM – The telomerase inhibitor may also have disease-modifying properties, investigators suspect.
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Oral voxelotor improves hemoglobin in sickle cell disease
AMSTERDAM – The investigational agent may have disease modifying effects, researchers reported.
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Adjuvant immunotherapy results ‘encouraging’ in early NSCLC
CHICAGO – About one-fifth of patients with resectable non–small cell lung cancer had major pathological responses with atezolizumab monotherapy...
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Nivo/ipi shrinks early NSCLC before surgery
CHICAGO – Among patients who went on to resection, 44% of those who had received neoadjuvant nivolumab and ipilimumab had a major pathological...
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More liberal criteria could greatly expand clinical trial participation
CHICAGO – A proof-of-concept study suggests that broader inclusion criteria could nearly double participation in clinical trials for non–small...
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Novel enfortumab vedotin induces responses in advanced urothelial cancers
CHICAGO – The investigational drug showed encouraging responses in patients with heavily pretreated locally advanced...
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Racial disparities in time to cancer care erased with Medicaid expansion
The gap in timely access to care between African Americans and whites diagnosed with advanced solid tumors disappeared with the Affordable Care...
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TITAN trial yields big survival benefits in mCSPC
CHICAGO – Adding apalutamide to androgen deprivation therapy significantly improved overall survival of castration-...
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Ribociclib/ET improves OS in premenopausal women with HR+/HER2- breast cancer
CHICAGO – Adding ribociclib to an aromatase inhibitor or tamoxifen was associated with an 29% relative reduction in...
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Ribociclib plus endocrine therapy boosts survival of HR+/HER2- breast cancer
CHICAGO – The overall survival rate at 42 months was 70% in the combined therapy group, vs. 46% for patients treated...
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Short-term ADT improves radiation salvage after prostatectomy
CHICAGO – 10-year metastasis-free survival was superior for patients who received goserelin plus radiation for...
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Pexidartinib gets ODAC nod for tenosynovial giant cell tumor treatment
Missing efficacy data from the pivotal ENLIVEN trial and adverse liver events were points of contention.
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FDA panel not ready to recommend quizartinib approval for FLT3-ITD+ AML
SILVER SPRING, MD. – A small clinical benefit, questions about the validity of the data, and concerns about cardiovascular adverse events point to...
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High pCR rate in HPV+ HNSCC with nivolumab/SBRT
ATLANTA – Nine of 10 patients in a phase 1/1b trial had pathologic complete responses to neoadjuvant nivolumab and radiation.
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Subcutaneous or IV trastuzumab? Take your pick
Long-term follow-up of women with early, HER2-positive breast cancer showed similar efficacy and safety for subcutaneous or intravenous...