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Skin Barrier Dysfunction and Atopic Dermatitis in Early Infancy

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In early infancy, distinct parental and pregnancy-related factors are predictive for dry skin, high transepidermal water loss (TEWL), and atopic dermatitis (AD), a new study found. Researchers aimed to identify parental, prenatal and perinatal predictive factors of dry skin, high TEWL and AD at age 3 months, and to determine if dry skin or high TEWL at age 3 months can predict AD at age 6 months. They found:

  • 1,150 mother-child pairs were included in the analysis.
  • Significant predictive factors for dry skin at age 3 months were delivery >38 gestational weeks and paternal age > 37 years, for high TEWL; male sex, birth during winter season and maternal allergic disease, and for eczema; multiparity, and maternal allergic diseases.
  • Dry skin at age 3 months was predictive for AD 3 months later.

Citation:

Rehbinder EM, et al. Predicting skin barrier dysfunction and atopic dermatitis in early infancy. [Published online ahead of print September 27, 2019]. J Allergy Clin Immunol Pract. doi: 10.1016/j.jaip.2019.09.014.

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