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Sleep Fragmentation in Stroke

Does it contribute to arteriosclerosis and infarcts?

Publish date:: January 26, 2016

Sleep fragmentation is associated with arteriolosclerosis and subcortical infarcts in older adults, according to a study of structured brain autopsies of 315 participants in the Rush Memory and Aging Project. Researchers found:

Greater sleep fragmentation was associated with more severe arteriosclerosis (OR=1.27) and more subcortical macroscopic infarcts (OR=1.31).

These associations were independent of established cardiovascular risk factors and diseases, and several medical comorbidities.

Citation: Lim ASP, Yu L, Schneider JA, Bennett DA, Buchman AS. Sleep fragmentation, cerebral arteriolosclerosis, and brain infarct pathology in community-dwelling older people. [Published online ahead of print January 14, 2016]. Stroke. doi: 10.1161/STROKEAHA.115.011608.

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