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Radiologically Isolated Syndrome and PPMS
Is evolution greater among the RIS population?
Patients with radiologically isolated syndrome (RIS) evolve to primary progressive multiple sclerosis (PPMS) at the same frequency as expected from general MS populations in an age-dependent manner, according to a study of 453 patients with RIS. Researchers found:
- 128 patients evolved to symptomatic MS during follow up.
- PPMS prevalence (11.7%) and onset age (49.1 years) in the RIS group were comparable to other PPMS populations.
- Median time to PPMS was 3.5 years.
- RIS evolved to PPMS more commonly in men and at an older age vs CIS/MS, independent of follow-up duration.
- Patients who evolved to PPNS had more spinal cord lesions (100%) before symptomatic evolution than those who developed CIS/MS (64%) and those who remained asymptomatic (23%).
- Other MRI characteristics in the preprogressive phase of PPMS were indistinguishable from CIS/MS.
Citation: Kantarci OH, Lebrun C, Siva A, et al. Primary progressive multiple sclerosis evolving from radiologically isolated syndrome. [Published online ahead of print December 29, 2015]. Ann Neurol. doi: 10.1002/ana.24564