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Measuring PD Fatigue with Modified Fatigue Impact Scale
Parkinsonism Relat Disord; ePub 2017 Jul 20; Kluger, et al
The Modified Fatigue Impact Scale (MFIS) is a valid multidimensional measure of fatigue in Parkinson's disease (PD) with demonstrable minimally clinically important difference (MCID), according to a recent study. While several fatigue scales are partially validated in PD, the MCID is unknown for any scale but is an important psychometric value to design and interpret therapeutic trials. Researchers thus sought to determine the MCID for the MFIS by conducting a secondary data analysis from 94 PD participants in an acupuncture trial for PD fatigue. Standard psychometric approaches were used to establish validity and an anchor-based approach was used to determine the MCID. They found:
- The MFIS demonstrated good concurrent validity with other outcome measures and high internal consistency.
- MCIDs values were found to be 13.8, 6.8, and 6.2 for the MFIS total, MFIS cognitive, and MFIS physical subscores, respectively.
Kluger BM, Garimella S, Garvan C. Minimal clinically important difference of the Modified Fatigue Impact Scale in Parkinson's disease. [Published online ahead of print July 20, 2017]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2017.07.016.