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PPI users show no increased risk of dementia

Publish date:: October 5, 2020

Key clinical point: Use of proton pump inhibitors (PPIs) was not associated with an increased risk of dementia and was associated with a 30% reduction in risk compared to no PPI use (adjusted hazard ratio 0.67).

Major finding: In a multivariate analysis, the incidence of dementia was 11.4% among PPI users and 12.3% among individuals not exposed to PPIs over an average follow-up period of 13 years.

Study details: The data come from a population-based study of 183,968 adults aged 55 years and older using the Secure Anonymised Information Linkage (SAIL) Databank, Wales, United Kingdom, from 1999 to 2015.

Disclosures: The study was conducted as conducted as part of the Health Data Research–UK (HDRUK) project and the National Centre for Population Health and Wellbeing Research. The researchers had no financial conflicts to disclose.

Citation:

Cooksey R et al. Plos One. 2020 Sept 18. doi: 10.1371/journal.pone.0237676.

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