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Alcohol-induced loss of consciousness boosts dementia risk

Publish date:: October 5, 2020

Key clinical point: Alcohol-induced loss of consciousness was significantly associated with an increased risk of dementia regardless of overall alcohol consumption and may be a long-term risk factor.

Major finding: Over an average follow-up period of 14.4 years, 0.8% of study participants developed dementia and 10.4% reported loss of consciousness as a result of alcohol consumption; the hazard ration for dementia was twice as high for those with loss of consciousness for both men and women (HR 2.86 and 2.09, respectively).

Study details: The data come a multicohort study including 131,415 adults aged 18 to 77 years who reported alcohol consumption and had no dementia at baseline study enrollment.

Disclosures: The study was supported in part by the IPD-Work consortium with funding from NordForsk; the UK Medical Research 10 Council, the Academy of Finland, the Helsinki Institute of Life Science, and the National Institute on Aging. Lead author Dr. Kivimäki was the recipient of funding from the IPD-Work consortium, but had no other financial conflicts to disclose.

Citation:

Kivimäki M et al. JAMA Network Open. 2020 Sept 9. doi:10.1001/jamanetworkopen.2020.16084.

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