Key clinical point: The increased risk of severe GI bleeding in older persons using low-dose aspirin is concentrated in individuals with a handful of risk factors.

Major finding: The risk of serious upper GI bleeding events was increased 87% in the aspirin users, while serious lower GI bleeding was increased by 36%.

Study details: ASPREE was a clinical trial of more than 19,000 apparently healthy older adults randomized to 100 mg/day of enteric-coated aspirin or placebo and followed prospectively for roughly 5 years.

Disclosures: The study’s first author reported having no financial conflicts.