Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Treatment for Pediatric Low-Grade Glioma Associated With Poor Cognitive Outcomes

Publish date:: August 13, 2019

Key clinical point: Treatment for low-grade pediatric tumors entails long-term cognitive and socioeconomic decrements.

Major finding: At follow-up, mean IQ was 93.9 for surgery plus radiotherapy, 101.2 for surgery alone, and 108.5 for unaffected siblings.

Study details: An examination of 286 participants in the Childhood Cancer Survivor Study.

Disclosures: The National Cancer Institute supported the study. The authors had no disclosures.

Citation:

Ris MD et al. Cancer. 2019 Jun 24. doi: 10.1002/cncr.32186.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,

Must Reads in Neuro-oncology

Genomic analysis reveals insights into pathogenesis of neuroblastoma,

Early results ‘encouraging’ for CAR NKT cells in neuroblastoma,

Evaluating the impact of new pediatric brain tumor classifications,

WHO-defined IDH molecular subgroups predict adjuvant chemotherapy benefits in low-grade glioma,

QoL Good for MGMT-Methylated Glioblastoma Patients With Lomustine-Temozolide,