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Impact of Obesity and Metabolic Syndrome in CRC
J Clin Oncol; ePub 2016 Sep 6; Feliciano, et al
Patients with early-stage colorectal cancer (CRC) who are obese and have metabolic syndrome have worse overall and CRC-related survival, according to a study involving nearly 2,500 individuals.
Investigators grouped participants based on presence or absence of metabolic syndrome, as well as obesity. Among the results:
• 601 patients died, 325 from CRC at a median follow-up of 6 years.
• Obese participants with metabolic syndrome had a 45% higher mortality risk than nonobese patients without metabolic syndrome.
• The risk was 9% higher for those who were not obese but had metabolic syndrome.
• Obese patients who did not have metabolic syndrome did not have a higher mortality risk.
• Those with obesity and metabolic syndrome had a 49% higher risk of CRC-related death; these odds increased with the number of metabolic syndrome components present.
Feliciano E, Kroenke C, Meyerhardt J, et al. Metabolic dysfunction, obesity, and survival among patients with early-stage colorectal cancer. [Published online ahead of print September 6, 2016]. J Clin Oncol. doi:10.1200/JCO.2016.67.4473.