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Immune Response & Obesity-Related Colorectal Cancer

Int J Cancer; ePub 2016 Mar 31; Hanyuda, et al

Publish date:: April 12, 2016

A vigorous immune response does not particularly hinder obesity-related cancer, according to a study of 1,798,029 men and women, including 1,436 incident rectal and colon cancer cases with available tumor tissue and pathological immunity data. Researchers found:

• Body mass index (BMI) was significantly associated with higher risk of overall colorectal cancer.

• The association of BMI with colorectal carcinoma risk did not significantly differ by the level of lymphocytic reaction or T-cell infiltration in tumor tissue status.

• A vigorous immune response does not particularly hinder obesity-related cancer.

• Being obese increases risk of colorectal cancer, and a vigorous T-cell response can improve colorectal cancer prognosis.

Citation: Hanyuda A, Ogino S, Rong Qian Z, et al. Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate. [Published online ahead of print March 31, 2016]. Int J Cancer. doi:10.1002/ijc.30122.

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