Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
These Levels Rise Over Time in Some with VWD
Am J Hematol; ePub 2017 Nov 17; Abou-Ismail, et al
A significant rise in von Willebrand factor antigen (VWF:Ag), VWF activity (VWF:RCo), and Factor VIII (FVIII) levels were seen over time in a retrospective cohort study involving 126 individuals with a certain type of von Willebrand disease (VWD) or low VWF. Investigators looked at VWF:Ag, VWF:RCo, and FVIII levels in participants with either type 1 VWD or low VWF. Among the results:
- Overall, over ~10 years, 28% attained normal levels of both VWF:Ag and VWF:RCo.
- 2 in every 10 patients with VWD achieved such.
- 3 in every 10 with low VWF did so.
- Statistically significant positive trends of VWF:Ag, VWF:RCo, and FVIII were seen over time (2.4, 1.4, and 1.4 U dL-1/year, respectively).
The authors noted that they were unable to determine if the bleeding phenotype also improves.
Abou-Ismail M, Ogungayo G, Secic M, Kouides P. Outgrowing the laboratory diagnosis of type 1 von Willebrand disease: A two-decade study. [Published online ahead of print November 17, 2017]. Am J Hematol. doi:10.1002/ajh.24962.