The patient-reported outcomes measurement information system (PROMIS) pediatric measures are feasible in a research setting and identify expected differences in known group comparisons in a sample of children with sickle cell disease (SCD). This according to a study of 235 children with SCD, aged 8 to 17 years, who completed PROMIS pediatric items using an online data collection platform. Researchers found:

• Adolescents, aged 12 to 17 years, reported significantly higher pain interference and depressive symptoms, and worse lower extremity physical functioning vs younger children, aged 8 to 11 years.

• Female patients reported significantly higher pain interference, fatigue, and depressive symptoms, and worse lower extremity physical functioning vs their male counterparts.

• Patients with hip or joint problems that limited usual activities reported significantly higher pain, fatigue, and depressive symptom scores, and worse upper/lower extremity physical functioning scores as did patients who had experienced sickle pain in the last 7 days.

Citation: Dampier C, Barry V, Gross HE, et al. Initial evaluation of the pediatric PROMIS® health domains in children and adolescents with sickle cell disease. [Published online ahead of print February 19, 2016]. Pediatr Blood Cancer. doi: 10.1002/pbc.25944.