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RT’s Impact on Survival in Older DLBCL Patients
Leuk Lymphoma; 2017 Mar; Parikh,Yahalom
Consolidation radiotherapy (RT) was linked with better overall survival in older patients with early-stage diffuse large B-cell lymphoma (DLBCL) receiving chemoimmunotherapy in a study involving more than 1,700 individuals.
Participants—all of whom had DLBCL and received chemoimmunotherapy with or without RT—were >60 years of age. Investigators looked at the link between RT and overall survival over an 11-year period ending in 2008. Among the results:
- RT use was linked with lower clinical stage, head/neck involved site, lack of 'B' symptoms, lower co-morbidity score, and higher socioeconomic status.
- The 5-year overall survival in patients receiving RT was 80%; vs 70% in those who did not receive such.
- After adjusting for certain variables, RT remained linked with improved overall survival.
- RT use decreased to 29% from 39% over the course of the study.
Citation:
Parikh R, Yahalom J. Older patients with early-stage diffuse large B-cell lymphoma: The role of consolidation radiotherapy after chemoimmunotherapy. Leuk Lymphoma. 2017;58(3):614-622. doi:10.1080/10428194.2016.1205739.