Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Must Reads by Date

Must reads for theWeek ending August 19, 2018

Improved myeloma outcomes associated with having prescription drug coverage, Olszewski A et al. J Clin Oncol. 2018 Aug 16. doi: 10.1200/JCO.2018.77.8894

For lymphoma patients, insurance is a matter of life or death , Goldstein JS et al. Blood. 2018 Jul 24. doi: 10.1182/blood-2018-03-839035

Expansion in clinical trial eligibility requested by ASCO, Friends of Cancer and ASCO letter to the FDA

Promise of broad genomic testing of NSCLC disappoints in community oncology , Presley CJ et al. JAMA. 2018 Aug 7. doi: 10.1001/jama.2018.9824

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Must reads for theWeek ending August 12, 2018

Higher AML, MDS risk linked to autotransplants, Radivoyevitch T et al. Leuk Res. 2018 Jul 19. pii: S0145-2126(18)30160-7

CMS wants to flatten E/M payments, CMS proposed rule, CMS-1693-P

Two novel TKIs better than one in GIST with multiple KIT mutations, Wagner AJ et al. ASCO 2018, Abstract 11509.

Lay health workers can assist with end-of-life care, Patel MI et al. JAMA Oncology. 2018 Jul 26. doi: 10.1001/jamaoncol.2018.2446.

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Must reads for theWeek ending August 5, 2018

Substantial late mortality risk persists after childhood BMT , Holmqvist AS et al. JAMA Oncol. 2018 Jul 26. doi: 10.1001/jamaoncol.2018.2453.

Avatrombopag reduces procedure-related transfusions in chronic liver disease and thrombocytopenia, Terrault N et al. Gastroenterology. 2018 May 17. doi: 10.1053/j.gastro.2018.05.025.

Simulated model could target myeloma treatment, Ubels J et al. Nat Commun. 2018 Jul 27. doi: 10.1038/s41467-018-05348-5.

Study evaluates surveillance intervals after Barrett's esophagus ablation, Cotton CC et al. Gastroenterology. 2018 Apr 12. doi: 10.1053/j.gastro.2018.04.011.

Pregnancy does not increase melanoma recurrence risk, DiSano JA et al. J Surg Res. 2018 Jun 16. doi: 10.1016/j.jss.2018.05.026.

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Must reads for theWeek ending July 22, 2018

Combo therapy after disease progression no advantage in chemotherapy-naïve metastatic castration-resistant prostate cancer, Attard G et al. Journal of Clinical Oncology; published online 20 July 2018. http://ascopubs.org/doi/abs/10.1200/JCO.2018.77.9827

Poorer RCC outcomes with incidental upstaging after partial nephrectomy, Russell C et al. Urology; July 2018, 95-100. https://doi.org/10.1016/j.urology.2018.04.002

Good results seen with laparoscopic partial nephrectomy following selective embolization of tumor, Benoit M et al. Clinical Genitourinary Cancer: Published online 12 July 2018 https://doi.org/10.1016/j.clgc.2018.07.005.

In metastatic hormone-sensitive prostate cancer, prior local therapy is linked to improved survival, Abdel-Rahman O and Cheung W. Clinical Genitourinary Cancer; published online 21 July 2018 https://doi.org/10.1016/j.clgc.2018.07.007

In sarcomatoid renal-cell carcinomas, 3-drug combo falls short, Maiti A et al. Clinical Genitourinary Cancer 2018 e47-e57 https://doi.org/10.1016/j.clgc.2017.07.028

More must reads

Must reads for theWeek ending July 22, 2018

Combo therapy after disease progression no advantage in chemotherapy-naïve metastatic castration-resistant prostate cancer, Attard G et al. Journal of Clinical Oncology; published online 20 July 2018. http://ascopubs.org/doi/abs/10.1200/JCO.2018.77.9827

Poorer RCC outcomes with incidental upstaging after partial nephrectomy, Russell C et al. Urology; July 2018, 95-100. https://doi.org/10.1016/j.urology.2018.04.002

Good results seen with laparoscopic partial nephrectomy following selective embolization of tumor, Benoit M et al. Clinical Genitourinary Cancer: Published online 12 July 2018 https://doi.org/10.1016/j.clgc.2018.07.005.

In metastatic hormone-sensitive prostate cancer, prior local therapy is linked to improved survival, Abdel-Rahman O and Cheung W. Clinical Genitourinary Cancer; published online 21 July 2018 https://doi.org/10.1016/j.clgc.2018.07.007

In sarcomatoid renal-cell carcinomas, 3-drug combo falls short, Maiti A et al. Clinical Genitourinary Cancer 2018 e47-e57 https://doi.org/10.1016/j.clgc.2017.07.028

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