Bleeding Disorders
Conference Coverage
VIDEO: Novel microcapsules show promise in hemophilia A with inhibitory antibodies
SAN DIEGO – Novel microcapsules loaded with factor VIII outperformed systemic factor VIII infusions in models of hemophilia A with inhibitory...
News
EC grants drug orphan designation for PNH
The European Commission (EC) has granted orphan drug designation to RA101495 for the treatment of paroxysmal nocturnal hemoglobinuria (PNH)....
Conference Coverage
Tinzaparin is a safe, effective anticoagulant in patients on dialysis
CHICAGO – Tinzaparin was safe and effective as an anticoagulant for hemodialysis patients based on results from the Intermittent Hemodialysis...
Conference Coverage
Factor VIII microcapsules eyed for eluding neutralizing antibodies
Using platelet microcapsules to deliver factor VIII, a process that is expected to increase factor VIII efficacy and avoid the development of...
From the Journals
Age of blood did not affect mortality in transfused patients
In-hospital mortality did not vary for patients who received transfusions of blood that had been stored for 2 weeks and for patients who got blood...
From the Journals
Calcium channel blocker reduces cardiac iron loading in thalassemia major
Amlodipine is a promising addition to chelation in patients with cardiac siderosis.
Conference Coverage
Extended half-life clotting factors are safe, effective, and pricey
ORLANDO – Early experience with extended half-life clotting factor concentrates suggests these products are generally safe and effective, at least...
From the Journals
Rivaroxaban linked to more bleeding compared with dabigatran in elderly patients with nonvalvular AF
Rivaroxaban is associated with significantly more intra- and extracranial bleeding than is dabigatran in older patients who have nonvalvular...
Conference Coverage
Planning, education smooth transition to longer-acting clotting factors
Key clinical point: Transitioning patients to extended half-life clotting factor concentrates requires tailoring treatment to individual patients...
News
IVIg, corticosteroids appear comparable for ITP in pregnancy
Most pregnant women with a history of immune thrombocytopenia purpura need no treatment. For those who do, neonatal outcomes are comparable when...
Conference Coverage
Early intensive prophylaxis provides better QoL in hemophilia
Key clinical point: Early initiation of intensive bleeding prophylaxis was associated with significantly better health-related quality of life (...