Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Effective Treatments for Collagenous Colitis

Cochrane; 2017 Nov 11; Kafil, et al

Publish date:: November 30, 2017

Budesonide appears to be effective in treating collagenous colitis, suggests a recent Cochrane review. A small study also found that bismuth subsalicylate (Pepto-Bismol), when compared to placebo, resolves the diarrhea brought on by the colitis. Among the other findings:

A placebo-controlled trial concluded that Boswellia serrata extract resolved diarrhea in 44% of patients, compared to 27% in the placebo group. but this small trial was deemed of very low quality.
A separate study found diarrhea cleared up in 80% of patients on budesonide, compared to 44% of those taking mesalamine; there were no differences between the drugs’ side effect profiles.

Citation:

Kafil TS, Nguyen TM, Patton PH, MacDonald JK, Chande N, McDonald J. Interventions for treating collagenous colitis. Cochrane Database of Syst Rev. 2017, Issue 11. Art. No.: CD003575. doi:10.1002/14651858.CD003575.pub6.

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