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Constipation-Related IBS Similar to Other IBS Types

Am J Gastroenterol; 2017 Jun; Peters, et al

Publish date:: July 13, 2017

The intestinal barrier and secretory functions of patients with constipation-predominant irritable bowel syndrome (IBS-C) do not seem to differ from those observed in healthy adults, according to researchers who tested a variety of intestinal functions in 19 IBS-C patients and compared them to normal persons. Among their findings:

Radioactive mannitol excretion, which measures saccharide excretion, did not differ significantly between the 2 groups.
There were also no significant differences in transmucosal resistance, a measure of the duodenal and colonic mucosal barriers.
The researchers did find laboratory evidence to suggest that basal duodenal secretion is decreased in patients with IBS-C.

Citation:

Peters SA, Edogawa S, Sundt WJ, et al. Constipation-predominant irritable bowel syndrome females have normal colonic barrier and secretory function. Am J Gastroenterol. 2017;112:913-923. doi:10.1038/ajg.2017.48.

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