The current approach to the diagnosis and monitoring of eosinophilic esophagitis (EoE) is invasive, expensive, and risky. A recent review of the medical literature suggests there are promising technologies available that may make the diagnosis safer, more accurate, and more cost effective.

• The current approach to EoE typically requires several esophagogastroduodenoscopies, sedation/anesthesia, numerous biopsies, the risk of complications, and financial hardship for patients and families.
• Several biomarkers are emerging as possible alternatives or complements to this approach, including absolute eosinophil counts, cytokines such as interleukin 4, 5, and 13, and chemokines such as eotaxin and mast cell tryptase.
• Other diagnostic tools supported by proof of concept evidence include transnasal endoscopy and saliva analysis for cytokines and miRNA.