Changes in disease location or behavior in patients with Crohn’s disease (CD) increase their risk of resection, a recent study found. The population-based inception cohort study identified clinical predictors associated with complicated CD between 2003-2004; 213 CD patients were followed prospectively until 2011. Associations between disease progression and/or resection, and multiple covariates, were investigated. Researchers found:

• 177 (83%) patients bad B1 at diagnosis.
• Patients who changed location had increased risk of disease progression (HR, 3.1).
• Biologic treatment was associated with lower risk of change in location (HR, 0.3).
• Colonic involvement was associated with a lower risk of surgery (HR, 0.34).
• All patients who progressed in behavior or changed location had an increased risk of surgery.