Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

IBD Linked to Several Monogenic Disorders

Inflamm Bowel Dis; 2018 Feb 15; Han, et al

Publish date:: March 8, 2018

Inflammatory bowel disease (IBD) appears to be associated with several monogenic disorders, according to an analysis of >55 million patient records. Researchers evaluated the link between Crohn’s disease, ulcerative colitis, and multiple Mendelian diseases, using a database from Optum’s electronic health record system that contained deidentified information. They found:

50 monogenic diseases were significantly associated with IBD, including 40 that were linked to both Crohn’s disease and ulcerative colitis.
Those associations focused primarily on disorders related to immune and metabolic processes and oxidative stress.

Citation:

Han L, Maciejewski M, Brockel C, et al. Mendelian disease associations reveal novel insights into inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):471-481. doi:10.1093/ibd/izx087.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Endoscopic intragastric balloon improved NASH parameters,

Autologous fecal microbiota transplantation helped maintain weight loss after ‘green’ Mediterranean diet,

Cryoballoon, cryospray found equivalent for eradicating Barret’s esophagus,

Must Reads in Crohn’s Disease

Ustekinumab & Health-Related Quality of Life in CD, J Crohns Colitis; ePub 2018 May 3; Sands, et al

Increased Risk of Acute MI and HF with IBD, Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al

Opioid Use Disorder & IBD Hospitalizations, J Crohns Colitis; ePub 2018 May 7; Cohen-Mekelburg, et al

Clinical Course of IBD with Celiac Disease, J Crohns Colitis; ePub 2018 May 7; Tse, et al

Incidence of Intestinal Infections in IBD, Inflamm Bowel Dis; ePub 2018 May 2; Barber, et al