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Inflammation, Sarcopenia Impact on CRC Survival
JAMA Oncol; ePub 2017 Aug 10; Cespedes Feliciano, et al
Inflammation that occurred before colorectal cancer (CRC) diagnosis was linked with sarcopenia at the time of diagnosis in a prospective cohort study involving nearly 2,500 individuals. Participants averaged 63 years of age and had stage I to III CRC diagnosed between 2006 and 2011. Investigators calculated skeletal muscle index, and looked at overall and CRC-related mortality. Among the results:
- 46% had a neutrophil to lymphocyte ratio (NLR) ≥3.
- 44% had sarcopenia.
- There were 656 deaths, including 357 from CRC, over a median of 6 years.
- Patients with an NLR from 3 to <5 were 35% more likely to experience sarcopenia, vs those with NLR <3.
- Patients with an NLR ≥ 5 were 47% more likely to experience such.
- Patients with an NLR >3 and sarcopenia had double the risk of both overall and CRC-related death.
The authors noted that paying close attention to these commonly-collected biomarkers could help predict survival.
Cespedes Feliciano E, Kroenke C, Meyerhardt J, et al. Association of systemic inflammation and sarcopenia with survival in nonmetastatic colorectal cancer: Results from the C SCANS Study. [Published online ahead of print August 10, 2017]. JAMA Oncol. doi:10.1001/jamaoncol.2017.2319.
This Week's Must Reads
Must Reads in Colon and Rectal
Fiber Intake and Survival After CRC Diagnosis, JAMA Oncol; ePub 2017 Nov 2; Song, Wu, et al
Cochrane on Detecting CRC in Patients with IBD, Cochrane; 2017 Sep 18; Bye, Nguyen, Parker, et al
Statins and Survival in Patients with Cancer, JAMA Oncol; ePub 2017 Aug 22; Emilsson, et al
Cochrane on Oral vs IV Chemotherapy for CRC, Cochrane; 2017 Jul 28; Chionh, Lau, Yeung, et al
Inflammation, Sarcopenia Impact on CRC Survival , JAMA Oncol; ePub 2017 Aug 10; Cespedes Feliciano, et al
