Key clinical point: The DEPDC1B gene restrained growth of tumors associated with HCC progression both in vitro and in vivo.
Major finding: Knockdown of DEPDC1B inhibited the progression of HCC by inhibiting cell proliferation, migration, and colony formation, also by promoting cell apoptosis in vitro.
Study details: The data come from an in vitro and in vivo analysis of DEPDC1B using immunohistochemical staining to detect expression in tumor tissues and normal tissues, and a xenograft model was used to show the functions of DEPC1B on tumor growth in vivo.
Disclosures: The study was supported by the National Natural Science Foundation of China (No. 81602100) and Natural Science Foundation of Shanghai. The researchers had no financial conflicts to disclose.
Source: Dang X-W et al. Aging. 2021 May 25. doi: 10.18632/aging.203016.