In a study that included participants from 3 large ongoing cohort studies, an association between genetic variants associated with circulating urate levels and risk of Parkinson disease (PD) was not supported. Researchers examined associations between single nucleotide polymorphisms (SNPs) in SLC2A9 and other genes involved in urate transport and PD risk using conditional logistic regression among 1,451 cases and 3,135 matched controls. They assessed associations between SNPs and plasma urate levels in a subset of 1,174 control participants with linear regression models. Among the findings:

• The associations between SNPs in SLC2A9 and plasma urate levels among men and women were observed.
• However, SNPs in other genes tended not be associated with urate.
• Each SNP in SLC2A9 explained <7% of the variance in plasma urate.
• Significant associations between the SNPs in SLC2A9 and PD risk among men or women were not found.