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This May Increase Atherosclerosis Risk in T2D Patients
Diabetes Care; ePub Feb 1, 2017; Saremi, et al
Certain advanced glycation end products and metabolic oxidation products are linked with the severity of subclinical atherosclerosis, according to a study involving 411 individuals.
Investigators measured baseline methylglyoxal hydroimidazolone, CEL, G-H1, 2-AAA, and methionine sulfoxide levels in participants with diabetes. ~10 years later they assessed carotid intima-media thickness (CIMT) via ultrasound, coronary artery calcification (CAC) via CT, and abdominal aortic artery calcification (AAC). Among the results:
- G-H1 was linked with the degree of CIMT and CAC.
- 2-AAA was strongly linked with the degree of CAC.
- CEL was strongly linked with the degree of AAC.
- The combination of G-H1 and 2-AAA products was strongly linked with subclinical atherosclerosis.
The authors noted that their findings may play an important role in macrovascular complications in people type 2 diabetes.
Saremi A, Howell S, Schwenke D, et al. Advanced glycation end products, oxidation products, and the extent of atherosclerosis during the VA Diabetes Trial and Follow-up Study. [Published online ahead of print February 1, 2017]. Diabetes Care. doi:10.2337/dc16-1875.