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Perineural Invasion of Cutaneous SCC Examined
JAMA Dermatol; ePub 2017 Jul 5; Karia, et al
Patients with cutaneous squamous cell carcinoma (CSCC) and clinical perineural invasion (CPNI) are at an increased risk of local recurrence and disease-specific death compared with patients with CSCC and incidental perineural invasion (IPNI) and have a 30% risk of death, according to a recent study. Researchers conducted a systematic review for English-language articles published since inception to November 11, 2016. All studies that reported a disease-related outcome of CSCCs with CPNI and IPNI were included. They found:
- A total of 12 studies containing 241 patients with CPNI and 381 patients with IPNI were included in the systematic review and analysis.
- The overall risks of local recurrence and disease-specific death were significantly higher in patients with CSCC and CPNI compared with those with CSCC and IPNI.
- The risks of nodal metastasis and distant metastasis did not differ significantly by PNI classification.
- Patients with CSCC and CPNI had poorer mean 5-year recurrence-free survival and disease-specific survival compared with patients with IPNI.
Karia PS, Morgan FC, Stamell Ruiz E, Schmults CD. Clinical and incidental perineural invasion of cutaneous squamous cell carcinoma. A systematic review and pooled analysis of outcomes data. [Published online ahead of print July 5, 2017]. JAMA Dermatol. doi:10.1001/jamadermatol.2017.1680.